Indiana's state capital, Indianapolis is a busy government and commercial center boasting a thriving university campus and a vibrant array of cultural attractions. Established in an unnavigable location on the White River, the city failed to thrive until the 1860s when it became a Civil War rail and transportation hub. Pharmaceutical company Eli Lilly is a dominant economic and cultural force here. Monument Circle forms the focal point of downtown. Indianapolis Motor Speedway draws throngs each year to the venerable Indianapolis 500, the largest single-day sporting event in the world. Football fans brave the cool autumn to cheer on the Indianapolis Colts at Lucas Oil Stadium.